Монография предназначена для специалистов в области социальной философии, социологии и истории, а также для широкого круга читателей.

Purpose. Reconstruction of Empedocles’ doctrine from the point of view of philosophical anthropology. Theoretical basis. Methodological basis of the article is the anthropological comprehending of Empedocles’ text fragments presented in the historical-philosophical context. Originality. Cognition of nature in Ancient Greece was far from the ideal of the objective knowledge formed in modern times, cognition of the world as it exists before man and independently of him. Whatever the ancient philosophers talked about, man was always in the center of their attention. (...) I proposed an anthropological version of the interpretation of the doctrine of Empedocles, within the framework of which various elements of his concept fit into a consistent model. Conclusions. Empedocles’ anthropology is based on the recognition of several fundamental things. First of all, there is no death. Second, there is no fundamental difference between human and celestial. This line is conventional and under certain conditions one can overcome it. Cod can become a human, and a human can become God. Teaching of evolution is also double. Not only physical shell evolves, keeping only the most adapted species, but the soul too. The latter can both ascend to the gods and go down to the bushes and fish. Purification of the soul and mastering the magic of the elements gives an impetus for a correct direction of evolution. Empedocles is an anthropologist-practitioner, who shows by his example that a human can cope with all the elements and reach divinity. He chose the elemental ingredients for penetrating the Fortunate Isles, leaving the instructions on how to become God. (shrink)

Neurosteroid 17 beta-estradiol (E2) is a steroid synthesized de novo in the nervous system that might influence neuronal activity and behavior. Nevertheless, the impact of E2 on the functioning of those neural systems in which it is slightly synthesized is less questioned. The vestibulo-ocular reflex (VOR) adaptation, may provide an ideal arena for investigating this issue. Indeed, E2 modulates cerebellar parallel fiber-Purkinje cell synaptic plasticity that underlies encoding of VOR adaptation. Moreover, aromatase expression in the cerebellum of adult rodents is (...) maintained at very low levels and localized to Purkinje cells. The significance of age-related maintenance of low levels of aromatase expression in the cerebellum on behavior, however, has yet to be explored. Our aim in this study was to determine whether E2 synthesis exerts an effective and persistent modulation of VOR adaptation in adult male rats. To answer this question, we investigated the acute effect of blocking E2 synthesis on gain increases and decreases in VOR adaptation using an oral dose (2.5 mg/kg) of the aromatase inhibitor Letrozole in peri-pubertal and post-pubertal male rats. We found that Letrozole acutely impaired gain increases and decreases in VOR adaptation without altering basal ocular-motor performance and that these effects were similar in peri-pubertal and post-pubertal rats. Thus, in adult male rats neurosteroid E2 effectively modulates VOR adaptation in both of the periods studied. These findings imply that the adult cerebellum uses E2 synthesis for modulating motor memory formation and suggest that low and extremely localized E2 production may play a role in adaptive phenomena. (shrink)